Aspirin resistance in cardiovascular disease: a review.
نویسندگان
چکیده
BACKGROUND Aspirin is effective at reducing the cardiovascular event rate in defined patient groups. The introduction of antiplatelet therapies other than aspirin and the concept of aspirin resistance have led to critical reappraisal of current treatment. This review aims to clarify the evidence for aspirin resistance in patients with atherosclerosis. METHODS Medline search was performed to identify publications concerned with antiplatelet effects of aspirin and failure of aspirin therapy. Manual cross referencing was also performed. RESULTS AND CONCLUSION Wide variations in the rate of aspirin resistance (5.5-75%) have been reported. The lack of consensus on an appropriate definition and the number of different tests used to investigate aspirin resistance needs to be addressed. There are few studies where the primary aim was to document aspirin resistance or aspirin non-response. Further work should aim to investigate if aspirin resistance is clinically important and, if it is, what treatments may be beneficial to the at risk patient.
منابع مشابه
Prevalence rate of aspirin resistance in cardiovascular disease patients: A systematic review and meta-analysis
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عنوان ژورنال:
- European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
دوره 27 5 شماره
صفحات -
تاریخ انتشار 2004